Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women with an estimated prevalence of 6–8%. Women with PCOS have a known increased prevalence of prediabetes (30–40%), type 2 diabetes (T2DM 10%), and metabolic syndrome (40%). We determined the prevalence of recorded PCOS through a structured primary care based T2DM screening programme.Methodology: Eligibility criterion for a structured and systematic sc...

Objective: To assess the effect of antithyroid drug pretreatment on radioiodine (I-131) treatment outcomes for benign thyroid disease.Method: Retrospective analysis of all patient records on the clinical database that underwent I-131 treatment for benign thyroid disease between 1989 and 2007.Results: About 544 patients were identified, 98 males (18%) and 446 females (82%). The mean age was 54 years (11-88). 464 patients (85.3%) we...

Introduction: Graves’ disease is a common cause of hyperthyroidism in pregnant woman, but usually improves during pregnancy.Case: A 23-year-old Pakistani woman in her first pregnancy had no personal or family history of thyroid disease. At 30 weeks gestation she developed a swollen, red left eye, which progressed to involve the right eye. Orbital MRI demonstrated left-sided proptosis, bulky superior and inferior rectus muscles, but no extra-orbital ...

We hypothesised that normal regulation of 25(OH)D3-24-hydroxylase (encoded by CYP24) determines the autocrine/paracrine action of 1,25(OH)2D3 in normal breast and prostate epithelial cells. Furthermore, these processes are compromised in malignancy.We therefore studied the regulation of CYP24, amongst a panel of breast and prostate cancer cell lines (ZR-75-1, T47-D, MCF-7, MDA-MB-231 breast cells and LNCaP, PC-3 and DU-145 prostate cells) that display d...

Introduction: Liquid biopsies have revolutionised cancer care, from accurate diagnosis to guiding treatment and surveillance. Here, we used shallow Whole Genome Sequencing (sWGS); a cost-effective and easy-to-perform test to explore concordance of copy number alterations (CNAs) between formalin-fixed paraffin-embedded (FFPE) tissue extracted DNA and circulating cell-free DNA (cfDNA) in patients with Thyroid Cancer (TC) during different stages of the disease. <...

Case 1: A 57-year-old lady referred to the Endocrinology department due to a CT Abdomen, performed for abdominal pain, reporting the presence of an incidental left adrenal adenoma. Imaging was reviewed in the Adrenal MDT meeting and further CT Abdomen arranged. Images were reviewed before and after oral contrast. Pre-contrast images revealed a small volume of high-density material within a rounded structure in the left upper quadrant, immediately superior to t...

Introduction: 48,XYYY is a rare condition where two extra Y chromosomes alter the neurological, skeletal and reproductive development of the affected individual. Clinical features are usually subtle and the diagnosis is not suspected until fertility issues arise. Here, were report an adult patient with 48,XYYY in the Endocrinology Clinic.Case report: A 24-year-old male was referred to UHL Endocrinology Clinic following i...

Introduction: Testosterone <5nmol/l is commonly seen in conditions such as PCOS however when testosterone is >5nmol/l, concerns start to rise about more sinister causes. Here, we present a case of a female who was referred to clinic with testosterone >5mmol/lCase: A 32 year old presented to the GP with a heavier than usual menstrual period. For an unknown reason, the GP checked testosterone, which came back a...

Background: Adrenal insufficiency (AI) requires life-long glucocorticoid substitution therapy (1), and bears significant risks of infection, cardiovascular (CV) & metabolic disease burden. Historically Hydrocortisone (HC) has been the mainstay of treatment. Prednisolone is a once-daily alternative due to a longer half-life (up to 3.2 hrs). Currently, there is no discernible evidence supporting the superiority of either medication (2).Objective: To ex...

Background: Primary adrenal insufficiency or Addison’s disease (AD) is characterized by glucocorticoid and mineralocorticoid deficiency due to lesion of the adrenal glands through different mechanisms (1). Addison’s disease is a risk factor for adverse maternal and neonatal outcomes. Close monitoring is required for these patients during the intrapartum and postpartum periods.(2)Objective: Retrospective evaluation of the management of Addison&#...